A note on power approximations for the transmission/disequilibrium test.
نویسنده
چکیده
The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.
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عنوان ژورنال:
- American journal of human genetics
دوره 64 4 شماره
صفحات -
تاریخ انتشار 1999